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Your Questions About Carnitine Deficiency

July 6, 2012
By


Thomas Your Questions About Carnitine Deficiency

Thomas asks…

I have been advised to start taking ginkgo biloba and Ginseng, L-carnitine and Coenzyme Q10.Long term effects?

I have been advised to start taking ginkgo biloba and Ginseng, L-carnitine and Coenzyme Q10.Will there be any long term effects?
My mum takes Ginkgo biloba and has stopped for a month and her memory and brain are always muddled and forgetful.
My worry is that once you start taking these things you need to stick with them?
Surely if you start taking, your body stops producing and therefore if you don’t take them you end up with a deficiency?
Any advice would be great, many thanks
Advised by my doctor for CFS

admin answers:

Advised by whom and for what purpose?

Sharon Your Questions About Carnitine Deficiency

Sharon asks…

Can I take 5-HTP, SAMe, tyrosine, l-carnitine and CoQ-10 together?

I have been suffering from on and off depression for most of my young adult life (i’m 19 years old at the moment), and am getting a number of possible organic causes tested for. I have had diabetes, celiac disease and nutritional deficiencies ruled out, and am next attempting to rule out allergies, mineral imbalances, toxicity, and hypto-thyroidism. If these don’t result in any breakthroughs i’m resorting to self- medicating for depression.

I plan to take SAMe and tyrosine in the morning, l carnitine and CoQ-10 a few hours later, and 5-HTP right before I go to sleep. Is there a possibility of any negative reactions among these drugs?

admin answers:

In almost all vitamin stores and health food stores, I have seen sections of the store devoted to “brain supplements” or “mood enhancers.” Many of the ingredients in the brain and mood products are in combination form. In other words, a product in the Vitamin Shoppe, for example, might contain the amino acids L-carnitine and L-tyrosine plus herbs like ginkgo biloba and St. John’s wort, and possibly CoQ10, phosphatidyl serine, 5-HTP, etc.

Research on St. John’s wort suggests it can be helpful for mild (or maybe moderate) depression. However, what many people don’t know is that it can take at least 3 weeks to start working. This herb can also interact with some medications. So you should ask a health care professional about any possible bad interaction if you are taking any prescription medication.

I suggest you start with St. John’s wort since it has been researched more methodically than the other products you mentioned.

The products you mentioned may or may not be helpful for you. There is not a lot of scientific proof that they work. There is only speculation and “testimonials.”

I suggest you avoid SAMe. I go to a weekly mood support group for people with depression, bipolar disorder, etc. SAMe is very expensive and I have never heard anyone report that it helped them.

Finally, I doubt there would be negative interactions in the products you mentioned. Most of them have been sold in combination forms for years.

For myself, I found exercise to be a very potent antidepressant. I also practice relaxation techniques like meditation. Psychotherapy has also been helpful for me.

Sandy Your Questions About Carnitine Deficiency

Sandy asks…

biochem q on LCAD and glycogen storage diseases?

Fraternal twins have episodes of fasting hypoglycemia, hypoketonemia, and muscle weakness
occurring only during periods of caloric deprivation.
One twin dies at 5 months of age.
The
surviving twin develops a cardiomyopathy, which is diagnosed at 3 years of age.
Carnitine esters
are elevated in muscle tissue and in serum.
Which of the following is the most likely diagnosis?
A.
a-L-Iduronidase deficiency hunters
B.
Acid maltase deficiency (a 1,4-glucosidase deficiency) pompes
C.
Carnitine uptake deficiency
D.
Long-chain acyl CoA dehydrogenase (LCAD) deficiency
E.
Muscle glycogen phosphorylase deficiency mcardles

i was torn between B and D on this q…since carnitine levels were high then id say D. but what else could distinguish this answer of d being correct? i said pompes aka b first since the infant died and it was a heart problem plus the symptoms were aggrevated in times of not eating. pompes is a glycogen storage disease where a lysozomal enzyme doesnt break down glyocgen so if someone didnt eat and needed the glycogen theyd be screwed with this genetic disorder. any help is appreciated.

admin answers:

I agree that the elevated carnitine levels point to answer D. But I am not sure of this. What mystifies me is why these children do not have elevated ketones.

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Your Questions About Carnitine Deficiency

July 1, 2012
By


Sharon Your Questions About Carnitine Deficiency

Sharon asks…

anyone heard of Carnitine deficiency?

my friend was told her baby girl has got this just over a month ago but as it is very uncommon shes not really been given any information she is 9 months old and suffers with fits but they dont no what cause them as a result she is now blind with a little brain damge (they wont no how much till she is older) she was a normal healty little girl before all this so anyone with any information at all with what to expect or anything at all answers much appeciated thanks in advanced

admin answers:

Http://en.wikipedia.org/wiki/Primary_carnitine_deficiency

Thomas Your Questions About Carnitine Deficiency

Thomas asks…

Is anyone familiar with a condition called Phosphorlase B Kinase Deficiency?

I was diagnosed with this condition along with Metabolic Myopathy with a Carnitine Deficiency. This was found when they did a muscle biopsy on me to try to find answers for me and my son who has the same health problems that I have.
We have flare-ups where we aren’t able to do anything for days at a time, nothing…then we have our “good days” when we can actually function.
Doctors don’t know too much about this, still trying to find out. I really want answers to try to help my son. He has to be home schooled because during his flare-ups he would miss too much school. And he really wants to be in school, he would actually be in the high school. It is so heart-breaking watching him go through this. It is bad enough that I have to live with it, but devastating to see him like this. Any help, any at all, is greatly appreciated.

admin answers:

I found out what it is in simple terms-
phosphorylase b kinase deficiency /phos·phor·y·lase b ki·nase de·fi·cien·cy/ an X-linked disorder of glycogen storage due to deficiency of the enzyme in the liver, characterized in affected males by hepatomegaly, occasional fasting hypoglycemia, and some growth stunt.

Dorland’s Medical Dictionary for Health Consumers. © 2007 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

I have tried looking for ore information on this condiction but this was all I can come up with.Is there any organizations that support the cause of this. Smethimes doctors offices have support groups and phamplets laying around that way you can find out more about the condiction. Sorry this was I can come up with.

Joseph Your Questions About Carnitine Deficiency

Joseph asks…

is there a connection mcad deficiency and uti’s?

my 3yr old daughter was diagnosed with mcad deficiency and has been taking a carnitine supplement to help her kidneys get rid of toxins is there a connection between low carnitine levels and uti’s?

admin answers:

MCAD and the carnitine has nothing to do with uti’s. MCAD is a metabolic disorder and the carnitine is a naturally accuring enzyme that your daughter can’t make. The toxins are also building up in the liver so I dont think this would cause and uti’s. My son was diagnosed when he was 5 days old in october 2006. He is now a very happy, healthy and active 19 month old.

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Your Questions About Carnitine Deficiency

June 28, 2012
By


Mandy Your Questions About Carnitine Deficiency

Mandy asks…

What is Carnitine Deficiency?

I would like to know what is Carnitine Deficiency?

admin answers:

Carnitine Deficiency Syndromes

http://www.webmd.com/hw/health_guide_atoz/nord60.asp

this article is more indepth

http://www.emedicine.com/ped/topic321.htm

Plz let me know if you need further help in searching this syndrome.

Richard Your Questions About Carnitine Deficiency

Richard asks…

pyruvate oxidation in carnitine deficiency?

i know that pyruvate oxidation in carnitine deficiency is not impaired. i’m just not sure why. can someone please explain? i’d really appreciate it. thanks icon smile Your Questions About Carnitine Deficiency

admin answers:

Why would pyruvate oxidation be impaired? Carnitine is a fatty acid carrier.
W

Lizzie Your Questions About Carnitine Deficiency

Lizzie asks…

Is there a difference between “carnitine deficiency” and an “SCADD” (short chain deficiency)?

My son died 2 hours after an induced labor (37 weeks) of “metabollic acidosis” coupled with severe anemia. I was on two epilepsy meds, depakote (which depletes carnitine levels — mine were LOW but they didn’t know this till later) and zonegran (which killed my appetite, resulting in fasting which is apparently horrible if you’re already low on carnitine). They found he was carnitine deficient and/or had an SCADD — it didn’t occur to me until now — are these two separate things? Can the SCADD be a result of a carnitine deficiency linked to the depakote? (They have no idea what caused the anemia, other than possibly bleeding into the placenta after the cord was cut.) I am still puzzling over this…thanks!

admin answers:

According to nih.gov:
“Primary carnitine deficiency is a condition that prevents the body from using fats for energy, particularly during periods without food (fasting).”
I know this is for primary cases, and you’re suggesting this case was medication induced, but that was all I could find icon sad Your Questions About Carnitine Deficiency .

SCADD on the other hand is discussed more as a autosomal recessive genetic disorder. So each time you have a child, there may be a 25% chance of having it again in that child. The children tend to get hypoglycemic which can result in the metabolic acidsosis.

I wish I knew more. It sounds like you are worried that your medications may have somehow worsened all this and I’m very sorry for your loss. Personally as an MD student, it does not sound like your medications should have contributed much. If they did, then it was your doctor’s responsibility to take you off the meds and maybe on a safer alternative. I hope you feel better. I’ll leave the links for you in case you are interested in reading on it.

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