Posts Tagged ‘ Carnitine Deficiency ’

Your Questions About Carnitine

September 19, 2012
By


Paul Your Questions About Carnitine

Paul asks…

Is L-Carnitine worth taking, or should I just stick to a healthy diet without supplements?

I have read that L-Carnitine can speed up weight loss?

Has anyone taken it? If so, what were the results??

admin answers:

The way it naturally occurs L-Carnithine helps your muscles repair themselves after a strenuous work out. This repair is the source of muscle growth and an elevated resting metabolism. So in small doses it can help you burn calories faster. I have noticed a small difference in body fat, body composition but not necessarily weight loss. Excessive amounts of this or any vitamin will only result in more expensive contents in your septic tank and may overstress your kidneys, so . . . If a little is good, more is NOT better.

Ruth Your Questions About Carnitine

Ruth asks…

is there a good support group for people who have primary carnitine deficiency?

i was just told i have this rare muscle desease and i would like to talk with others who have the same.
thank you but no this is not fabry deases. it was a confimed carnitine def.

admin answers:

Is this Fabry Disease ?

Anyway here are some links to support groups for carnitine deficiency support.

Hope they help.

Richard Your Questions About Carnitine

Richard asks…

How Can I Flush Acetyl L-Carnitine From My System?

I began taking the supplement to clear my mind. It worked beautifully, but, I began having constant stomach upset, but, didn’t know why. This morning, after I took my latest-and last-dose, I saw that my condition is one of the side effects of the this supplement.
Is there anything I can take to flush it out of my system, or will I just have to let it work itself out of my system, and how long does that usually take?
Thanks, in advance, for any & all informed answers.

admin answers:

You are going to have to let it pass.

You should completely feel better in 24-48 more hours.

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Your Questions About Carnitine Deficiency

August 20, 2012
By


Steven Your Questions About Carnitine Deficiency

Steven asks…

Pretty Important Medical Question?!?

So, in January, I had a freak case of Rhabdomyolysis. I’m 16 years old, and I went to the hospital presented with myoglobinuria (if that’s how you say it). No pain, no stiffness (after I exercised I had pretty bad stiffness, but it went away the next day), nothing when I was admitted…. They did a blood test, and my CK levels came out at 492,000. My potassium levels were also high…I think…either high or low. I was hospitalized, and my CK levels dropped at about 120,000 per day…and 4 days later I was released from the hospital. It was kind of odd, because from what my doc said, people with rhabdo in my situation already have renal damage, and are usually in the ICU on dialysis. I was discharged perfectly fine. My doctor, nor none of the Emergency Medicine Residents could figure out why I got it. My family physician really wanted me to go see a GI doc and a Renal doc. I went to go see a GI doc and he found nothing. I knew something was up, and since I’m in a Emergency Med program at my school, I decided to look into to things. After looking for a few months, I think I have something called Carnitine Palmitoyltransferase 2 deficiency (CPT-2 deficiency).

Website since the disorder is rare:

http://ghr.nlm.nih.gov/condition/carnitine-palmitoyltransferase-2-deficiency

I do get muscle stiffness and pain a lot when I exercise…..Many of the symptoms it gave me, explained me perfectly, especially with the rhabdo. So what’s the next step? Do I call my doctor immediately, or can I just tell her at my next physical?

admin answers:

You certainly need to see your own doctor again, but not necessarily in a hurry. Even if you do have CPT-2 deficiency (and there are other possibilities) there has to be a trigger for the rhabdomyolysis. If you avoid fasting and energetic exercise, you will be fine until the next appointment. When you talk to your own doctor, I suggest you avoid presenting your own diagnosis (if I were your doctor, I would be tempted to respond by suggesting you organise your own treatment as well). Instead, raise the entirely appropriate question that you might have a genetic condition and might benefit from consulting a genetic specialist.

Mandy Your Questions About Carnitine Deficiency

Mandy asks…

Vitamin and Mineral Supplement Question’s?

I have been doing some research regarding deficiency‘s associated with Vaplroic Acid, and from what I have read there are vitamins and minerals that can be taken to reduce these deficiency‘s. In particular:
Selenium — 100-200mcg daily.
L-Carnitine — 500-1000mg three times daily.
Vitamin D — 600 IU daily.
Calcium — 200mg daily.
Vitamin B12 — 30mcg daily.
Vitamin B6 — a lower dose??
Possibly a supplement of Biotin.

I would just like to know if anybody has/is taking valproic acid and has experienced side effects such as fatigue, shakiness, hard time getting to sleep, and staying asleep, blurry vision, head ache, and has been taking the medication for more then 6 months. I am at a dosage of 250mg twice daily of Valproic Acid treating Epilepsy, having one serious seizure almost a year ago, 17 years old, 5’7, 150 lbs, and run 5km 3 days a week. If anyone has knowledge of these supplements and if they may help with these side effects i would like to know. As well are these supplement doses reasonable??, and anything else to consider with these supplements such what to mix, what not to mix?? times of day?
Another question about melatonin, is it safe to use on Valproic Acid and will it help with my sleep?
Thanks!

admin answers:

Vitamin D lack, or just hypovitaminosis , is undoubtedly widespread for People in america, particularly those that are living in wintry, upper environments, also as the aged population. This really is because our own potential to generate the particular vitamin lowers as we grow older.

Within the active condition, cholecalciferol goes thru your bloodstream, focusing on a number of bodily organs, which include brain, impacting on just what exactly that particular organ really does. Vitamin D3 will be vital for the purpose of regulating tissues growing, improving calcium and also phosphorus ingestion, keeping immunity process integrity and cardiovascular system healthiness. This may possibly be involved when it comes to tumors reduction. Essential vitamin D3 may help to keep our blood calcium mineral degrees good for making bone as well as the teeth, muscles contracting, as well as the relocating for neurological impulses.

When it comes to emotional health condition and learning, this important vitamin has a tendency to trigger receptors on nerves in portions of your brain liable for actions adjustment. This boosts release of important brain chemical substances and also defends the brain by being free radical cleansing. Vitamin D also performs as the anti- — inflammatory agent up against general problems.

Helen Your Questions About Carnitine Deficiency

Helen asks…

herbal adderall…. any exist? Looking for use for recreational purposes for energy, focus, and fatloss?

Adderllin.com
This product contains..

Vitamin B3
Is a B vitamin with Nootropic effects. It is also has been noted for its use in people with Alzheimer’s disease.

Vitamin B12
Is involved in the metabolism of every cell of the body, especially affecting the DNA synthesis and regulation but also fatty acid synthesis and energy production. Vitamin B12 deficiency can cause severe and irreversible damage, especially to the brain and nervous system. Vitamin B-12 gives a great natural energy boost.

Guarana
Guarana is an herb that is rich in caffeine. Research has also shown that guarana may affect how quickly the body perceives itself to be full as well.

Bitter Orange
Bitter orange is used as a stimulant and appetite suppressant which aids in weight loss. It contains several alkaloids such as synephrine that stimulate the body’s beta-3 receptors. Activating these receptors boosts your metabolic rate and energy levels to help increase fat burning and ultimately body fat loss. It also promotes the release of epinephrine and nor-epinephrine which boost mental energy and focus while indirectly helping body fat loss.

Yohimbe Bark Extract
It is of the tryptamine chemical class with stimulant and aphrodisiac effects. It is also known for it’s thermogenic effect. Like adderall® it is classified as pycho-stimulant that has Nootropic behavior.

Choline Dihydrogen Citrate
It is a naturally-occuring ammonium salt that is found in the lipids that make up cell membranes -in the neurotransmitter acetylcholine. Choline is the chemical precursor or “building block” needed to produce the neurotransmitter acetylcholine, and research suggests that memory, intelligence, and mood are mediated at least in part by acetylcholine metabolism in the brain.

Acetyl-L-Carnitine
ALCAR has neuroprotective benefits in the treatment of Parkinson’s disease. ALCAR plays many important roles in the body, but the most important one from a fat burning perspective is ALCAR’s role in escorting fatty acids to the cell’s mitochondria where they can be burned as fuel aiding in body fat loss.

Bacopa Extract
It has been used in India for several thousand years and is considered a “brain tonic” which enhances memory development, learning, and concentration thus fighting attention deficit hyperactivity disorder (ADHD). The herb shows significant psychotropic action as evidenced by excessive sleep and conformation changes in the brain as well as blood. It is also a potent antioxidant.

Acetyl-L-Tyrosine
Tyrosine is converted in the body to key biologic compounds. These compounds include epinephrine, dopamine, L-dopa, Co-Q10, and thyroid hormones.

Caffeine
Caffeine has nootropic effects, inducing positive changes in memory and learning. Both caffeine and naturally occurring caffeine found in guarana called guaranine are found in Adderllin.

Dimethylaminoethanol
DMAE is related to choline and is a biochemical precursor to the neurotransmitter acetylcholine. Studies have shown an increase in vigilance and alertness, with a positive influence on mood.

White Willow Bark Extract
White willow bark extract is added because a synergy occurs whenever ingredients are combined and the specific combination of those ingredients provides a greater benefit than the individual benefits that could be realized if each of those ingredients were taken independent of each other. Also known as a natural pain reliever.

Piperine
Piperine is an extract found from black pepper and is known for it’s increased uptake of nutrients and supplements.

Vinpocetine
Is an extract found in the periwinkle plant. Vinpocetine is reported to have a cerebral blood-flow enhancing and neuroprotective effects. It is also used as a drug in eastern european countries for the treatment of cerebrovascular disorders and age related memory impairment.

Huperzine
Is naturally occurring and extracted from the Firmoss plant. Huperzine has been shown to enhance memory and learning performance in clinical trials performed on China

I hope this helped people who want to take an herbal alternative for recreational use.

admin answers:

Nice website – I was surprised at its functionality.
I was also pleased to see the ingredients listed there as well – it sounds like a dynamite combination.
I would have been happier to see a percentage or the mg of the separate ingredients for quality control.
In time the FAQs may need to be expanded to include answers about norepinephrine and serotonin and MAO inhibition
This is not a nutritional supplement for conditions such as Parkinson’s disease although some constituents most certainly are such as Piperine. Because some ingredients function as AChE inhibitors, it would be contraindicated but that is a reason for using for AD.

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Your Questions About Carnitine Deficiency

July 6, 2012
By


Thomas Your Questions About Carnitine Deficiency

Thomas asks…

I have been advised to start taking ginkgo biloba and Ginseng, L-carnitine and Coenzyme Q10.Long term effects?

I have been advised to start taking ginkgo biloba and Ginseng, L-carnitine and Coenzyme Q10.Will there be any long term effects?
My mum takes Ginkgo biloba and has stopped for a month and her memory and brain are always muddled and forgetful.
My worry is that once you start taking these things you need to stick with them?
Surely if you start taking, your body stops producing and therefore if you don’t take them you end up with a deficiency?
Any advice would be great, many thanks
Advised by my doctor for CFS

admin answers:

Advised by whom and for what purpose?

Sharon Your Questions About Carnitine Deficiency

Sharon asks…

Can I take 5-HTP, SAMe, tyrosine, l-carnitine and CoQ-10 together?

I have been suffering from on and off depression for most of my young adult life (i’m 19 years old at the moment), and am getting a number of possible organic causes tested for. I have had diabetes, celiac disease and nutritional deficiencies ruled out, and am next attempting to rule out allergies, mineral imbalances, toxicity, and hypto-thyroidism. If these don’t result in any breakthroughs i’m resorting to self- medicating for depression.

I plan to take SAMe and tyrosine in the morning, l carnitine and CoQ-10 a few hours later, and 5-HTP right before I go to sleep. Is there a possibility of any negative reactions among these drugs?

admin answers:

In almost all vitamin stores and health food stores, I have seen sections of the store devoted to “brain supplements” or “mood enhancers.” Many of the ingredients in the brain and mood products are in combination form. In other words, a product in the Vitamin Shoppe, for example, might contain the amino acids L-carnitine and L-tyrosine plus herbs like ginkgo biloba and St. John’s wort, and possibly CoQ10, phosphatidyl serine, 5-HTP, etc.

Research on St. John’s wort suggests it can be helpful for mild (or maybe moderate) depression. However, what many people don’t know is that it can take at least 3 weeks to start working. This herb can also interact with some medications. So you should ask a health care professional about any possible bad interaction if you are taking any prescription medication.

I suggest you start with St. John’s wort since it has been researched more methodically than the other products you mentioned.

The products you mentioned may or may not be helpful for you. There is not a lot of scientific proof that they work. There is only speculation and “testimonials.”

I suggest you avoid SAMe. I go to a weekly mood support group for people with depression, bipolar disorder, etc. SAMe is very expensive and I have never heard anyone report that it helped them.

Finally, I doubt there would be negative interactions in the products you mentioned. Most of them have been sold in combination forms for years.

For myself, I found exercise to be a very potent antidepressant. I also practice relaxation techniques like meditation. Psychotherapy has also been helpful for me.

Sandy Your Questions About Carnitine Deficiency

Sandy asks…

biochem q on LCAD and glycogen storage diseases?

Fraternal twins have episodes of fasting hypoglycemia, hypoketonemia, and muscle weakness
occurring only during periods of caloric deprivation.
One twin dies at 5 months of age.
The
surviving twin develops a cardiomyopathy, which is diagnosed at 3 years of age.
Carnitine esters
are elevated in muscle tissue and in serum.
Which of the following is the most likely diagnosis?
A.
a-L-Iduronidase deficiency hunters
B.
Acid maltase deficiency (a 1,4-glucosidase deficiency) pompes
C.
Carnitine uptake deficiency
D.
Long-chain acyl CoA dehydrogenase (LCAD) deficiency
E.
Muscle glycogen phosphorylase deficiency mcardles

i was torn between B and D on this q…since carnitine levels were high then id say D. but what else could distinguish this answer of d being correct? i said pompes aka b first since the infant died and it was a heart problem plus the symptoms were aggrevated in times of not eating. pompes is a glycogen storage disease where a lysozomal enzyme doesnt break down glyocgen so if someone didnt eat and needed the glycogen theyd be screwed with this genetic disorder. any help is appreciated.

admin answers:

I agree that the elevated carnitine levels point to answer D. But I am not sure of this. What mystifies me is why these children do not have elevated ketones.

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Your Questions About Carnitine

July 4, 2012
By


Ken Your Questions About Carnitine

Ken asks…

Why and How does green tea and L-Carnitine help on weight management?

There is a food supplement in our local drugstore containing 250mg of green tea extract (EGCG) and L-Carnitine 250 mg. There are people I know who actually lost weight gradually from 5 to 10 lbs in 2 weeks. With Diet and Exercise. How does it work? And how many milligrams are really needed per EGCG and L-Carnitine?

admin answers:

2g

Linda Your Questions About Carnitine

Linda asks…

Are there long term effects of supplementing glutamine or BCAA or Carnitine?

I’ve recently started taking L-Glutamine and Branched Chain Amino Acids for weight lifting and working out. I’ll also be getting into carnitine when I start cutting down.

My question is, are there any long term side effects for these three supplements? And will there be defficiencies when I decide to stop supplementing (as the body will no longer produce, because it’s been supplemented for so long)? And this brings me to another question (I’ve asked in diet/fitness category also), do you need to cycle any of these supplements?

And please, I would like to know facts and not just opinions. Thanks in advance!

admin answers:

I’ve had good effects from glutamine on liver–it’s supposed to be good, but I don’t know about the rest. Carnitine is found in meat, so it shouldn’t be bad for you. Here is what I looked up online and found:

Blood concentrations of branched chain amino acids (BCAA; leucine, isoleucine, and valine) and glutamine (Gln) decrease markedly in sepsis. We investigated the effect of carnitine on serum concentrations of BCAA and Gln in fasted septic rats. Rats were made septic by cecal ligation and puncture. They developed extremely high blood concentrations of endotoxin, and serum concentrations of BCAA and Gln were markedly decreased 2 d after the operation. When L-carnitine was administered subcutaneously to the rats at 500 mg/kg body weight every 12 h for 2 d starting at the operation, no decrease in the serum concentrations of BCAA and Gln was observed. This indicates that the administration of carnitine can prevent the decrease of serum concentrations of BCAA and Gln in septic animals.

John Your Questions About Carnitine

John asks…

What can you do to detect Carnitine Deficiency? Prenatal or later in a persons life.?

So, what kind of tests can you have done to tell if your baby has Carnitine deficiency? Would you have to wait until after they are born or can you tell by prenatal tests?

admin answers:

I think the tests are done only after birth. Check here.

Http://emedicine.medscape.com/article/942233-diagnosis

http://ghr.nlm.nih.gov/condition/primary-carnitine-deficiency

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Your Questions About Carnitine Deficiency

July 2, 2012
By


Lizzie Your Questions About Carnitine Deficiency

Lizzie asks…

Have any long-range side effects ( good or bad) been mapped for acetyl-l carnitine?

I have had acetyl-l-carnitine recommended as a memory aid, and am wondering if it is safe to use if I have not experienced any of the deficiencies described as an indication of the product. In other words, can one be harmed by taking it?

admin answers:

Apparently acetyl-l-carnitine has some small possible minor side effects as well as some benefits

Side Effects
1. Increase in blood pressure
2. Faster heartbeat
3. Fever and possible rash
4. Large amounts can lead to diarrhoea
5. Can cause nausea/vomiting, headache, bladder irritation or infection, unusual body odour, stuffy nose
6. Possibility of restlessness and difficulty sleeping due to the nature of the drug.

Benefits
1. It has a role in energy production and therefore a role in weight control
2. It can enhance cellular energy in the brain
3. It can alleviate the effects of depression
4. Can help to prevent cataracts
5. Can help those in a physically demanding job/hobby
6. Some studies have found evidence that acetyl-l-carnitine, might be helpful in Alzheimer’s disease
7. Uncontrolled studies suggest that L-carnitine or acetyl-L-carnitine may be helpful for improving sperm function.
8. Weak evidence also suggests that carnitine may be helpful for decreasing the toxicity of AZT (a drug used to treat AIDS).

Safety Issues
L-carnitine in its three forms appears to be quite safe. However, individuals with low or borderline-low thyroid levels should avoid carnitine because it might impair the action of thyroid hormone.
Individuals on dialysis should not receive this (or any other supplement) without a physician’s supervision. The maximum safe dosages for young children, pregnant or nursing women, or those with severe liver or kidney disease have not been established.

Interaction Drug Side Effects You Should Know About
If you are taking;
• Antiseizure medications, particularly valproic acid (Depakote, Depakene) but also phenytoin (Dilantin): You may need extra carnitine.
• Thyroid medication: Do not take carnitine except under a physician’s supervision

Like any drug, the possible side effects will affect people differently – due to metabolic factors – speak to your doctor for more information

Nancy Your Questions About Carnitine Deficiency

Nancy asks…

Has anyone had a someone with muscular dystrophy.?

My husband has carnitine deficiency and is doing very badly. Has anyone gone through this before and what should I expect

admin answers:

Muscular Dystrophy is a general term for several forms of dystrophies. The most common form is Duchene Muscular Dystrophy. Others are like Becker, Limb-girdle, Myotonic, and Congenital Muscular Dystrophy, just to name a few. They all seem to be caused by a genetic defect that causes a decrease in the production of dystrophin in the muscle, which leads to necrosis of the muscle. All of these various muscular dystrophies will have different clinical courses and affect different muscle groups. What you will expect is your physician can only sit back and watch because they do not have the magic bullet for this one. What you can do is start a regiment of healthy low glycemic meals (I can supply recipes) next a high quality supplement in high dose (it gives his God made body the ability to defend itself) next if you can walk 20-30 minutes a day. Contact me through my site for the specifics. Help is here.

Robert Your Questions About Carnitine Deficiency

Robert asks…

Starting a foundation?

I have hypoglycemia, particularly a carnitine deficiency. I want to start a foundation for those who have the same problem. I know there is already a Hypoglycemia Foundation, but I want to start one particularly for those with a carnitine deficiency, because there is a medicine for it, but that many might not be able to afford. It transforms the lives of those who need it, so I believe this is really a great cause. How would I go about starting this foundation?

admin answers:

The laws on starting the nonprofit company vary by state. There are a lot of services online that will do that for you, but it’s not hard to do it yourself. Look it up on your state’s secretary of state homepage. You can also found it in another state if you like their laws better – delaware is popular if i recall correctly.

Once you start your corporation you’ll need to get 501c3 status, which means filling out paperwork and sending money to the irs.

Once you have that you’ll be eligible for all sorts of grants from other foundations. If you can you might want to hire a grant writer, or recruit an experienced volunteer for that.

Side note – most (all?) pharmaceutical companies already have programs to help people who can’t afford their meds. You can probably check with the company about that.

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